Drosophila Interspecific Hybrids Phenocopy piRNA-Pathway Mutants
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چکیده
منابع مشابه
Drosophila Interspecific Hybrids Phenocopy piRNA-Pathway Mutants
The Piwi-interacting RNA (piRNA) pathway defends the germline of animals from the deleterious activity of selfish transposable elements (TEs) through small-RNA mediated silencing. Adaptation to novel invasive TEs is proposed to occur by incorporating their sequences into the piRNA pool that females produce and deposit into their eggs, which then propagates immunity against specific TEs to futur...
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The regulation of gene expression is essential for organismal form, function, and fitness. Complex organismal development from zygote to adult requires finely tuned expression of genes in space, time, and abundance. Proper expression of genes is also required for most other aspects of physiology and function. Even minor changes in gene expression have the potential to significantly impact pheno...
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Male hybrids between three pairs of Drosophila species show no substantial distortion of Mendelian segregation and no appreciable male recombination. These results do not support the theories that meiotic drive alleles of large effect are often fixed within species and that transposable genetic elements cause speciation.
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Maintenance of genome integrity in germ cells is crucial for the success of future generations. In Drosophila, and mammals, transposable element activity in the germline can cause DNA breakage and sterility. Recent studies have shown that proteins involved in piRNA (PIWI-interacting RNA) biogenesis are necessary for retrotransposon silencing in the Drosophila germline. Females mutant for genes ...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2012
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1001428